Botox will now carry the Food and Drug Administration’s strictest warning for pharmaceuticals after the agency raised concerns over the risk of botulism last year, Bloomberg reports. The approval of a rival botulinum toxin for cosmetic purposes prompted the review. The toxin can cause muscle weakness and breathing difficulty, particularly in non-approved applications for muscle spasms. Botox-maker Allergan’s shares fell 3% on the news. (More Botox stories.)