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Tim Burton and Johnny Depp's trip down the rabbit hole drew huge crowds, as Alice in the Wonderland earned a whopping $116.3 million in its opening weekend—a record for a 3-D film. That total easily surpassed all other films in release and gave Walt Disney Studios an even bigger opening than Avatar. It also marked the biggest opening weekend for a non-sequel.

"This is just one of those cultural phenomenons that has caught everybody's interest," said a Disney official. "They don't come like this very often." Other top grossers included Brooklyn's Finest with $13.5 million, Martin Scorsese's Shutter Island with $13.3 million, and Cop Out came with $9.1 million. (Read more Alice in Wonderland stories.)